mining of stroma in pthology

Artificial intelligence in digital pathology - new tools ...

In the past decade, advances in precision oncology have resulted in an increased demand for predictive assays that enable the selection and stratification of patients for treatment. The enormous divergence of signalling and transcriptional networks mediating the crosstalk between cancer, stromal and immune cells complicates the development of functionally relevant biomarkers based on a single ...

Translational AI and Deep Learning in Diagnostic Pathology

There has been an exponential growth in the application of AI in health and in pathology. This is resulting in the innovation of deep learning technologies that are specifically aimed at cellular imaging and practical applications that could transform diagnostic pathology. This paper reviews the different approaches to deep learning in pathology, the public grand challenges that have driven ...

Standardized Assessment of the Tumor-Stroma Ratio in ...

4Anatomopathological Diagnosis Center, Pathology Laboratory, João Pessoa, Paraíba, Brazil. ABSTRACT: The tumor stroma plays a relevant role in the initiation and evolution of solid tumors. Tumor-stroma ratio (TSR) is a histological feature that expresses the proportion of the stromal component that surrounds cancer cells.

Targeting the tumor stroma: integrative analysis reveal ...

Prognostic stroma-related genes were subject to literature data mining in terms of association with tumor stroma and malignancies. Henshall et al. (2001) reported that AR expression in tumor epithelium and stroma that is associated with a poor clinical outcome in prostate cancer, on the other hand, AR is emerging as a potential new therapeutic ...

A distinct microglial subset at the tumor–stroma interface ...

Mar 11, 2021· Using data mining and analyses of samples derived from both murine and human sources we show that PGAM exhibit a pro-inflammatory and chemotactic phenotype that is associated with peripheral monocyte recruitment, and decreased overall survival. PGAM act as a unique subset of GAM at the tumor–stroma interface.

Mining Brain Metastasis for Answers < Pathology

Feb 25, 2021· Mining Brain Metastasis for Answers. ... They found changes in thousands of genes in the tumor cells and stromal cells, induced by the tumor microenvironment (TME). ... Associate Professor of Pathology to identify distinct and …

Pathology Outlines - Fibrous dysplasia

Dec 30, 2020· Intervening fibrous stroma containing cytologically bland spindle cells, without prominent cytologic atypia Mitotic figures rare Stromal changes, including myxoid change and fatty metaplasia, may be seen in some cases (BMC Musculoskelet Disord 2003;4:20) Secondary aneurysmal bone cyst-like changes may also be seen (Turk Patoloji Derg 2018;34:234)

Endometrial Stromal Hyperplasia: An Underrecognized Condition

Jan 29, 2013· Hyperplasia of the endometrial stroma is a poorly recognized lesion, lacking widespread recognition with most, if not all, such cases sequestrated in the literature as endometrial stromal nodules or low-grade endometrial stromal sarcomas. In this paper, we describe three examples of "endometrial stromal hyperplasia" which have a remarkable morphological similarity with the normally ...

on the Sample Form. DO NOT EXCEED FOUR PAGES

stroma in comparison to normal stroma for prostate cancer. A. Positions and Honors. Position and Employment 2006-2007 Postdoctoral Scholar, Botany and Plant Science, University of California, Riverside 2007-2008 Specialist, Pathology and Laboratory Medicine, University of California, Irvine

Su-In Lee, University of Washington, "Mining Big Data for ...

Sep 06, 2016· " Mining Big Data for Molecular Marker Detection ... The other method applied to ovarian cancer data led to a potential molecular driver for tumor-associated stroma, in collaboration with UW Pathology and UW Genome Sciences. Our methods are general computational frameworks and can be applied to many other diseases.

Types of Ovarian Tumors - Johns Hopkins Pathology

Types of Ovarian Cancer. There are three main types of ovarian tumors: Epithelial tumors - derived from the cells on the surface of the ovary. This is the most common form of ovarian cancer and occurs primarily in adults. Germ cell tumors - derived from the egg producing cells within the body of the ovary. This occurs primarily in children and ...

Mining TCGA database for genes of prognostic value in ...

Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression profiling and database mining for potential correlation between genes and overall survival of a variety of malignancies including …

Ocular Pathology: Herpes Simplex Virus Stromal Keratitis

Definition: Herpes simplex virus keratitis is a viral infection of the cornea caused by Herpes simplex. It is characterized in early stages by a linear arborizing pattern of opacification and swelling of epithelial cells called a dendrite (green arrow represent the histologic appearance of …

Succinate dehydrogenase deficient gastrointestinal stromal ...

Feb 21, 2021· Succinate dehydrogenase deficient gastrointestinal stromal tumors (SDH-deficient GISTs), which lack KIT or PDGFRA mutations demonstrate unique clinical and pathological features, and they respond poorly to standard targeted therapy. We herein present a novel case of SDH-deficient GIST in a three-month-old infant's colon mesentery, and he is the youngest patientto date.

Ovarian Cancer & Ovarian Pathology - Ovarian Cancer ...

Ovarian Cancer. Ovarian cancer is a group of diseases that originate in the ovaries, or in the related areas of the fallopian tubes and the peritoneum. The ovaries are a woman's reproductive organs. Women have two ovaries that are located in the pelvis—one on each side of the uterus. The ovaries have a size and shape comparable to a large olive.

Visiopharm Research Solutions - Propelling pathology forward

Tumor-stroma separation Various image analysis algorithms in oncology depend on a reliable tumor-stroma separation prior to the detailed analysis to ensure precise data generation. Our deep learning based tumor detection for IHC accurately identifies regions of epithelial tumor cells and can be combined with a variety of ready-to-use or ...

Cells | Free Full-Text | The Importance of Stromal ...

A summary since the first immunohistochemical description in 1998 until 2019 is provided. The emphasis was on classification of endometrial implants into glands, stroma, and both together. The most remarkable finding is the very high percentage of stromal endomesis of …

Phyllodes Tumor of the Breast - Surgical Pathology Criteria

Lacks significant stromal hypercellularity: Hypercellular stroma is prominent : No stromal overgrowth : May have stromal overgrowth : No leaf-like architecture : Prominent leaf-like architecture : No condensation around ducts : Stromal condensation around ducts : Does not infiltrate : May infiltrate surrounding breast

Utilizing Digital Pathology to Quantify Stromal Caveolin-1 ...

Aug 18, 2021· Loss of stromal caveolin-1 (Cav-1) is a biomarker of a cancer-associated fibroblast (CAF) phenotype and is related to progression, metastasis, and poor outcomes in several cancers. The objective of this study was to evaluate the clinical significance of Cav-1 expression in invasive epithelial ovarian cancer (OvCa). Epithelial and stromal Cav-1 expression were quantified in serous OvCa and ...

Cell Pathology - De Gruyter

Aug 07, 2012· Cell Pathology is a new title re-launched in 2020 in place of Endoplasmic Reticulum Stress in Diseases journal. Cell Pathology is an open-access, peer-reviewed journal that focuses on the abnormal state of cells driven by cell-intrinsic or extrinsic influences that manifest in changes of the morphology, loss of homeostasis, and/or alternations in the genetic profiles of cells. The journal ...

(PDF) Machine Learning and Artificial Intelligence–driven ...

Patient summary This mini-review reports recent advances in machine learning and artificial intelligence for spatial analysis of the tumor immune microenvironment in pathology slides.

Pathology of Prostatic Stromal Tumors of Uncertain ...

Jan 04, 2021· Stromal tumors arising from the specialized stroma of the prostate are uncommon proliferations with several histologic patterns. [1, 2] The term stromal tumors of uncertain malignant potential (STUMP) was coined to describe a proliferation of stromal cells that is behaviorally and histologically distinct from benign hyperplasia and whose behavior cannot be predicted by its histologic ...

Overexpression of matriptase in tumor stroma is a poor ...

Overexpression of matriptase in tumor stroma is a poor prognostic indicator of extrahepatic bile duct cancer. Toshihide bara. Department of Pathology, Jichi Medical University, 3311‐1 Yakushiji, Shimotsuke‐shi, Tochigi‐ken, Japan, 329‐0498.

Osterix-Cre marks distinct subsets of CD45- and CD45 ...

Aug 05, 2020· In the past couple of decades the common beliefs of how an incipient tumor grows and progresses to a metastatic stage have drastically changed due to the increasing findings of a tight crosstalk between tumor cells and the surrounding stroma, known as the tumor microenvironment (TME) (Hanahan and Weinberg, 2011).Tumor stroma comprises a variety of different cells from the …

(PDF) Artificial Intelligence in Lung Cancer Pathology ...

Oct 28, 2019· the feasibility of utilizing morphological features in pathology slides for lung cancer prognosis, which opened up an exciting new direction for reﬁning lung cancer prognosis using computer ...

Advances of AI in Digital Pathology

Jun 05, 2020· Advances of AI in Digital Pathology. In the last decade, advances in precision oncology have brought about increased demand for predictive assays that empower the choice and delineation of patients for treatment. The huge divergence of signalling and transcriptional systems intervening the crosstalk between cancer, stromal and immune cells ...

cord-gonadal stromal tumor | Osmosis

cord-gonadal stromal tumor Videos, Flashcards, High Yield Notes, & Practice Questions. Learn and reinforce your understanding of cord-gonadal stromal tumor. - Osmosis is an efficient, enjoyable, and social way to learn. Sign up for an account today! Don't study it, Osmose it.

Corneal Stromal Dystrophies - EyeWiki

The corneal dystrophies are a group of non-inflammatory, inherited, bilateral disorders of the cornea characterized by pathognomonic patterns of corneal deposition and morphological changes. The stromal subset of corneal dystrophies primarily affect the stroma, however, over time they often extend into the anterior corneal layers and some may affect Descemet's membrane and the endothelium ...

Myxoid stroma defined, confused : pathology

Myxoid stroma defined, confused. Close. 2. Posted by u/[deleted] 7 years ago. Archived. ... PSA for issues at the Department of pathology and laboratory medicine, Donald and Barbara Zucker School of Medicine. Hello everyone, this is a PSA for anyone applying for …

Endometrium: Secretory phase | Pathology Made Simple

May 23, 2016· Endometrium: Secretory phase. Glands : They are enlarged and dilated, with convolutions and are lined by columnar epithelium. The lining epithelium contains glycogen rich subnuclear vacuoles in the early secretary phase. The vacuoles will be supranuclear in midsecretary phase. In the late secretary phase, the glands are saw toothed and serrated ...

Mining of prognosis-related genes in cervical squamous ...

Purpose The aim of this study was to explore the effective immune scoring method and mine the novel and potential immune microenvironment-related diagnostic and prognostic markers for cervical squamous cell carcinoma (CSSC). Materials and Methods The Cancer Genome Atlas (TCGA) data was downloaded and multiple data analysis approaches were initially used to search for the immune-related scoring ...

In Response to "Reexamining the molecular findings in ...

Sep 08, 2021· Modern Pathology - In Response to "Reexamining the molecular findings in specialized stromal...

Stroma Definition & Meaning | Dictionary.com

Stroma definition, the supporting framework or matrix of a cell. See more.

Cord & Stromal Tumors

Sep 10, 2021· cord-stromal tumors account for approximately 2-5% of testicular neoplasms in adults but make up almost 25% of cases in children.The category includes pure cord and pure stromal tumors as well as mixed tumors with both components in varying proportions and unclassified tumors. The clinical behavior is benign in 90-95% of cases.Most tumors are non-functioning.

Data mining polycystic ovary morphology in electronic ...

Dec 01, 2019· Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia, oligo-anovulation, and numerous ovarian cysts. Hospital electronic medical records provide an avenue for investigating polycystic ovary morphology commonly seen in PCOS at a large scale. The purpose of this study was to develop and evaluate the performance of two machine learning text algorithms, for …

mining of stroma in pthology

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